Palladium-Catalyzed Decarboxylative Coupling of Alkynyl Carboxylic Acids and Aryl Halides

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• 作者：Jeongju Moon ; Mihee Jang ; Sunwoo Lee
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：February 6, 2009
• 年：2009
• 卷：74
• 期：3
• 页码：1403-1406
• 全文大小：149K
• 年卷期：v.74,no.3(February 6, 2009)
• ISSN：1520-6904

文摘

2-Octynoic acid and phenylpropiolic acid were employed for the palladium-catalyzed decarboxylative coupling reaction and with a variety of aryl halides. The former needed 1,4-bis(diphenylphosphino)butane (dppb) as a ligand and the latter tri-tert-butylphosphine (P^tBu₃), and both required 2 equiv of tetra-n-butylammonium fluoride (TBAF) for full conversion. These reactions showed high reactivities and tolerance of functional groups such as vinyl, ester, ether, ketone, and amine.