Gadolinium Complex of 125I/127I-RGD-DOTA Conjugate as a Tumor-Targeting SPECT/MR Bimodal Imaging Probe

详细信息    查看全文

• 作者：Ji-Ae Park ; Jung Young Kim ; Yong Jin Lee ; Wonho Lee ; Sang Moo Lim ; Tae-Jeong Kim ; Jeongsoo Yoo ; Yongmin Chang ; Kyeong Min Kim
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2013
• 出版时间：February 14, 2013
• 年：2013
• 卷：4
• 期：2
• 页码：216-219
• 全文大小：269K
• 年卷期：v.4,no.2(February 14, 2013)
• ISSN：1948-5875

文摘

The work describes the synthesis and in vivo application of [Gd(L)(H₂O)]路xH₂O, where L is a (¹²⁵I/¹²⁷I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (¹²⁵I/¹²⁷I-RGD)-DOTA signifies a 鈥渃ocktail mixture鈥?of radioisotopic (1a, L = ¹²⁵I-RGD-DOTA) and natural (1b, L = ¹²⁷I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

Keywords:

dual modality; SPECT/MR; RGD peptide; small molecule; tumor targeting