Application of the Photoredox Coupling of Trifluoroborates and Aryl Bromides to Analog Generation Using Continuous Flow
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- 作者：Travis J. DeLano ; Upul K. BandarageNatalie Palaychuk ; Jeremy Green ; Michael J. Boyd
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：December 16, 2016
- 年：2016
- 卷：81
- 期：24
- 页码：12525-12531
- 全文大小：433K
- ISSN：1520-6904
文摘
A method for the coupling of aryl bromides with potassium alkyl trifluoroborates, via nickel/photoredox dual catalysis, has been developed for use in continuous flow. This operationally simple protocol is able to form Csp3–Csp2 bonds with significantly reduced reaction times and a broader substrate scope than when conducted in batch. The utility of this method for rapid analog synthesis has been demonstrated by the synthesis of a small library of alkyl-substituted quinazolines.