Iodide-Catalyzed Reductions: Development of a Synthesis of Phenylacetic Acids

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• 作者：Jacqueline E. Milne ; Thomas Storz ; John T. Colyer ; Oliver R. Thiel ; Mina Dilmeghani Seran ; Robert D. Larsen ; Jerry A. Murry
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：November 18, 2011
• 年：2011
• 卷：76
• 期：22
• 页码：9519-9524
• 全文大小：296K
• 年卷期：v.76,no.22(November 18, 2011)
• ISSN：1520-6904

文摘

A new convenient and scalable synthesis of phenylacetic acids has been developed via the iodide catalyzed reduction of mandelic acids. The procedure relies on in situ generation of hydroiodic acid from catalytic sodium iodide, employing phosphorus acid as the stoichiometric reductant.