Preparation of Tetrasubstituted Furans via Intramolecular Wittig Reactions with Phosphorus Ylides as Intermediates

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• 作者：Tzu-Ting Kao ; Siang-en Syu ; Yi-Wun Jhang ; Wenwei Lin
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：July 2, 2010
• 年：2010
• 卷：12
• 期：13
• 页码：3066-3069
• 全文大小：215K
• 年卷期：v.12,no.13(July 2, 2010)
• ISSN：1523-7052

文摘

Novel preparation of tetrasubstituted furans, starting from the Michael acceptors, tributylphosphine, and acyl chlorides, is realized. A broad range of highly functional furans can be efficiently generated in one step at room temperature within 10 min to 21 h in moderate to high yields (60−99%). The reaction was proposed to proceed via intramolecular Wittig-type reactions, using phosphorus ylides as intermediates.