Copper-Catalyzed Trifluoromethylthiolation of Aryl Halides with Diverse Directing Groups

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• 作者：Jiabin Xu ; Xin Mu ; Pinhong Chen ; Jinxing Ye ; Guosheng Liu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：August 1, 2014
• 年：2014
• 卷：16
• 期：15
• 页码：3942-3945
• 全文大小：343K
• ISSN：1523-7052

文摘

The expansion of cross-coupling components in Cu-catalyzed C鈥揦 bond forming reactions have received much attention recently. A novel Cu-catalyzed trifluoromethylthiolation of aryl bromides and iodides with the assistance of versatile directing groups such as pyridyl, methyl ester, amide, imine and oxime was reported. CuBr was used as the catalyst, and 1,10-phenanthroline as the ligand. By changing the solvent from acetonitrile to DMF, the coupling process could even take place at room temperature.