Abietane and C20-Norabietane Diterpenes from the Stem Bark of Fraxinus sieboldiana and Their Biological Activities

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• 作者：Sheng Lin ; Yanling Zhang ; Mingtao Liu ; Sen Yang ; Maoluo Gan ; Jiachen Zi ; Weixia Song ; Xiaona Fan ; Sujuan Wang ; Yang Liu ; Yongchun Yang ; Xiaoguang Chen ; Ying Guo ; Wenjie Wang ; Jiangong Shi
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：November 29, 2010
• 年：2010
• 卷：73
• 期：11
• 页码：1914-1921
• 全文大小：177K
• 年卷期：v.73,no.11(November 29, 2010)
• ISSN：1520-6025

文摘

Fourteen new abietane (1−14) and seven new C₂₀-norabietane (15−21) diterpenes, together with five known analogues, have been isolated from the stem bark of Fraxinus sieboldiana. Their structures were elucidated by spectroscopic data analysis. In the in vitro assays, at 10⁻⁵ M, compounds 8, 16, and 22 showed inhibitory activity against the release of β-glucuronidase in rat polymorphonuclear leukocytes induced by platelet-activating factor, with 59.7 ± 4.8%, 56.1 ± 5.6%, and 65.9 ± 3.1% inhibition, respectively. Compound 23 was active against H5N1 avian influenza virus with an IC₅₀ value of 4.8 μM. Compounds 3 and 5 exhibited selective cytotoxic activities against A2780 (IC₅₀ 1.7 μM) and A549 (IC₅₀ 6.0 μM), respectively.