Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652

详细信息    查看全文

• 作者：Xiao Zhou ; Hongbo Huang ; Yuchan Chen ; Jiaheng Tan ; Yongxiang Song ; Jianhua Zou ; Xinpeng Tian ; Yan Hua ; Jianhua Ju
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：December 28, 2012
• 年：2012
• 卷：75
• 期：12
• 页码：2251-2255
• 全文大小：274K
• 年卷期：v.75,no.12(December 28, 2012)
• ISSN：1520-6025

文摘

A new sequential tristhiazole-thiazoline-containing cyclic peptide, marthiapeptide A (1), was isolated from a 60 L scale culture of the deep South China Sea-derived strain Marinactinospora thermotolerans SCSIO 00652. The planar structure and absolute configuration of 1 were elucidated by application of spectroscopic techniques, as well as by single-crystal X-ray diffraction and chiral-phase HPLC analysis of the acid hydrolysates. Marthiapeptide A (1) exhibited antibacterial activity against a panel of Gram-positive bacteria, with MIC values ranging from 2.0 to 8.0 渭g/mL, and displayed strong cytotoxic activity against a panel of human cancer cell lines with IC₅₀ values ranging from 0.38 to 0.52 渭M.