SERS-Encoded Nanogapped Plasmonic Nanoparticles: Growth of Metallic Nanoshell by Templating Redox-Active Polymer Brushes

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• 作者：Jibin Song ; Bo Duan ; Chenxu Wang ; Jiajing Zhou ; Lu Pu ; Zheng Fang ; Peng Wang ; Teik Thye Lim ; Hongwei Duan
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：May 14, 2014
• 年：2014
• 卷：136
• 期：19
• 页码：6838-6841
• 全文大小：270K
• 年卷期：v.136,no.19(May 14, 2014)
• ISSN：1520-5126

文摘

We report a new strategy to synthesize core鈥搒hell metal nanoparticles with an interior, Raman tag-encoded nanogap by taking advantage of nanoparticle-templated self-assembly of amphiphilic block copolymers and localized metal precursor reduction by redox-active polymer brushes. Of particular interest for surface-enhanced Raman scattering (SERS) is that the nanogap size can be tailored flexibly, with the sub-2 nm nanogap leading to the highest SERS enhancement. Our results have further demonstrated that surface functionalization of the nanogapped Au nanoparticles with aptamer targeting ligands allows for specific recognition and ultrasensitive detection of cancer cells. The general applicability of this new synthetic strategy, coupled with recent advances in controlled wet-chemical synthesis of functional nanocrystals, opens new avenues to multifunctional core鈥搒hell nanoparticles with integrated optical, electronic, and magnetic properties.