Suzuki-Miyaura Cross-Coupling Reactions of Unprotected Haloimidazoles

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• 作者：Jiajing Tan ; Yonggang Chen ; Hongmei Li ; Nobuyoshi Yasuda
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：September 19, 2014
• 年：2014
• 卷：79
• 期：18
• 页码：8871-8876
• 全文大小：473K
• ISSN：1520-6904

文摘

An efficient protocol for the palladium-catalyzed Suzuki鈥揗iyaura cross-coupling reaction of unprotected haloimidazoles is reported. The relatively mild reaction conditions allow for ready access to a wide array of functionalized imidazole derivatives in good to excellent yields. The synthetic utility of this method is demonstrated by the total synthesis of nortopsentin D.