Flavonoids Possess Neuroprotective Effects on Cultured Pheochromocytoma PC12 Cells: A Comparison of Different Flavonoids in Activating Estrogenic Effect and in Preventing 
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- 作者：Judy T. T. Zhu ; Roy C. Y. Choi ; Glanice K. Y. Chu ; Anna W. H. Cheung ; Qiu T. Gao ; Jun Li ; Zhi Y. Jiang ; Tina T. X. Dong ; Karl W. K. Tsim
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2007
- 出版时间：March 21, 2007
- 年：2007
- 卷：55
- 期：6
- 页码：2438 - 2445
- 全文大小：474K
- 年卷期：v.55,no.6(March 21, 2007)
- ISSN：1520-5118
文摘
Despite the classical hormonal effect, estrogen possesses a neuroprotective effect in the brain, whichhas led many to search for novel treatments for neurodegenerative diseases. Flavonoids, a group ofcompounds mainly derived from vegetables, share a resemblance, chemically, to estrogen, and indeed,some have been used as estrogen substitutes. To search for potential therapeutic agents againstneurodegenerative diseases, different subclasses of flavonoids were analyzed and compared withestrogen. First, the estrogenic activities of these flavonoids were determined by activating the estrogen-responsive elements in cultured MCF-7 breast cancer cells. Second, the neuroprotective effects offlavonoids were revealed by measuring its inhibition effects on the formation of reactive oxygenspecies, the aggregation of 
-amyloid, and the induction of cell death by -amyloid in cultured neuronalPC12 cells. Among these flavonoids, baicalein, scutellarin, hibifolin, and quercetin-3'-glucosidepossessed the strongest effect in neuroprotection; however, the neuroprotective activity did not directlycorrelate with the estrogenic activity of the flavonoids. Identification of these flavonoids could be veryuseful in finding potential drugs, or food supplements, for treating Alzheimer's disease.
-amyloid, and the induction of cell death by -amyloid in cultured neuronalPC12 cells. Among these flavonoids, baicalein, scutellarin, hibifolin, and quercetin-3'-glucosidepossessed the strongest effect in neuroprotection; however, the neuroprotective activity did not directlycorrelate with the estrogenic activity of the flavonoids. Identification of these flavonoids could be veryuseful in finding potential drugs, or food supplements, for treating Alzheimer's disease.