Synthesis of Fluorenes Starting from 2-Iodobiphenyls and CH2Br2 through Palladium-Catalyzed Dual C–C Bond Formation

详细信息    查看全文

• 作者：Guangfa Shi ; Dushen Chen ; Hang Jiang ; Yu Zhang ; Yanghui Zhang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：18
• 期：12
• 页码：2958-2961
• 全文大小：442K
• 年卷期：0
• ISSN：1523-7052

文摘

A facile and efficient approach is developed for the synthesis of fluorene and its derivatives starting from 2-iodobiphenyls and CH<sub>2sub>Br<sub>2sub>. A range of fluorene derivatives can be synthesized under relatively mild conditions. The reaction proceeds via a tandem palladium-catalyzed dual C–C bond formation sequence through the key dibenzopalladacyclopentadiene intermediates, which are obtained from 2-iodobiphenyls through palladium-catalyzed C–H activation.