Peroxynitrite (ONOO–) Redox Signaling Molecule-Responsive Polymersomes

详细信息    查看全文

• 作者：Jian Zhang ; Jun Hu ; Wei Sang ; Jianbo Wang ; Qiang Yan
• 刊名：ACS Macro Letters
• 出版年：2016
• 出版时间：August 16, 2016
• 年：2016
• 卷：5
• 期：8
• 页码：919-924
• 全文大小：444K
• 年卷期：0
• ISSN：2161-1653

文摘

Designing specific-responsive polymer nanocapsules toward a definite cell signaling molecule for targeted therapy faces a great challenge. Here we demonstrate that new block copolymer appended trifluoromethyl ketone side groups can chemoselectively respond to an endogenous redox biosignal, peroxynitrite (ONOO^–), but shield the interference of other biogenic reactive oxygen, nitrogen, and sulfur species (ROS/RNS/RSS). The ONOO^– signaling molecule is capable of triggering cascade oxidation–elimination reactions to cleave the side functionalities from the polymer chain, which induces a large alteration of the polymer amphiphilicity and further leads to controllable disassembly of their self-assembled vesicular structure. Modulating the ONOO^– stimulus concentrations could readily control the vesicle dissociation rates for desirable drug delivery. We envisage that this polymer model would provide a new scenario to construct bioresponsive macromolecular systems for future biomedical nanotechnologies.