Influence of LA and GA Sequence in the PLGA Block on the Properties of Thermogelling PLGA-PEG-PLGA Block Copolymers

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• 作者：Lin Yu ; Zheng Zhang ; Jiandong Ding
• 刊名：Biomacromolecules
• 出版年：2011
• 出版时间：April 11, 2011
• 年：2011
• 卷：12
• 期：4
• 页码：1290-1297
• 全文大小：982K
• 年卷期：v.12,no.4(April 11, 2011)
• ISSN：1526-4602

文摘

This paper reports the influence of sequence structures of block copolymers composed of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) on their thermogelling aqueous behaviors. A series of thermogelling PLGA-PEG-PLGA triblock copolymers with similar chemical compositions and block lengths but different sequences of d,l-lactide (LA) and glycolide (GA) in the PLGA block were synthesized. The difference of sequence structures arises from the different reactivities of LA and GA during the copolymerization and the transesterification after polymerization. The sol鈭抔el transition temperature and height of gel window were found to be regulated by the sequence structure. Our study reveals that the macromolecular sequence structure influences the hydrophobic/hydrophilic balance of this kind of amphiphilic copolymers and thus alters mesoscopic micellization and the forthcoming macroscopic physical gelation in water. This finding might be helpful to guide the molecular design of the underlying thermogelling systems as injectable hydrogels.