Polydopamine Coated Selenide Molybdenum: A New Photothermal Nanocarrier for Highly Effective Chemo-Photothermal Synergistic Therapy

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• 作者：Chao Wang ; Jing Bai ; Yuwei Liu ; Xiaodan Jia ; Xiue Jiang
• 刊名：ACS Biomaterials Science & Engineering
• 出版年：2016
• 出版时间：November 14, 2016
• 年：2016
• 卷：2
• 期：11
• 页码：2011-2017
• 全文大小：511K
• ISSN：2373-9878

文摘

Recently, two-dimensional transition metal dichalcogenides (TMDCs) have been widely studied in biomedicine. In this article, we developed a new photothermal nanocarrier based on polydopamine coated selenide molybdenum (MoSe₂@PDA) as an effective nanocarrier for loading anticancer drug doxorubicin (MoSe₂@PDA-Dox). Conjugation of PDA onto the surface of MoSe₂ nanosheets can not only enhance the photothermal effect of MoSe₂ nanosheets and decrease its cytotoxicity but also provide anchor points for loading Dox. The resulting MoSe₂@PDA nanocomposites exhibit good biocompatibility, good stability, and high photothermal conversion efficiency. The subsequent loading of anticancer drug doxorubicin (Dox) creates an efficient therapeutic agent with pH- and heat-responsive drug release. An in vivo experiment shows strong damage to tumor tissue, killing the tumor cell almost thoroughly. On that account, the MoSe₂@PDA-Dox nanocomposites may play a key role in cancer therapy in the future. Our work reveals the great promise of combing chemical and photothermal therapy to realize a synergistic effect for tumor treatment.