Khayseneganins A鈥揌, Limonoids from Khaya senegalensis

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• 作者：Chun-Mao Yuan ; Yu Zhang ; Gui-Hua Tang ; Ying-Tong Di ; Ming-Ming Cao ; Xiao-Ying Wang ; Guo-Ying Zuo ; Shun-Lin Li ; Hui-Ming Hua ; Hong-Ping He ; Xiao-Jiang Hao
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：March 22, 2013
• 年：2013
• 卷：76
• 期：3
• 页码：327-333
• 全文大小：365K
• 年卷期：v.76,no.3(March 22, 2013)
• ISSN：1520-6025

文摘

Eight new limonoids, khayseneganins A鈥揌 (1鈥?b>8), and 31 known limonoids were isolated from the leaves and twigs of Khaya senegalensis. The structures of the new compounds were elucidated by 2D-NMR spectroscopy and mass spectrometry, and the absolute configuration of 1 was determined by the CD exciton chirality method. Compounds 9, 10, 12, and 15 showed antimicrobial activities against Pseudomonas aeruginosa, MRSA 92^#, and MRSA 98^#, all with a MIC value of 12.5 渭g/mL.