Manadomanzamines A and B: A Novel Alkaloid Ring System with Potent Activity against Mycobacteria and HIV-1
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- 作者：Jiangnan Peng ; Jin-Feng Hu ; Abul B. Kazi ; Ze Li ; Mitchell Avery ; Olivier Peraud ; Russell T. Hill ; Scott G. Franzblau ; Fangqiu Zhang ; Raymond F. Schinazi ; Susan S. Wirtz ; Phillip Tharnish ; Michelle Kel
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：November 5, 2003
- 年：2003
- 卷：125
- 期：44
- 页码：13382 - 13386
- 全文大小：211K
- 年卷期：v.125,no.44(November 5, 2003)
- ISSN：1520-5126
文摘
Two novel alkaloids, named manadomanzamines A (1) and B (2), were isolated from anIndonesian sponge Acanthostrongylophora sp. (Haplosclerida: Petrosiidae). Their structures were elucidatedand shown to be a novel organic skeleton related to the manzamine type alkaloids. Their absoluteconfiguration and conformation were determined by CD, NOESY, and molecular modeling analysis. Themicrobial community analysis for the sponge that produces these unprecedented alkaloids has also beencompleted. Manadomanzamines A (1) and B (2) exhibited strong activity against Mycobacterium tuberculosis(Mtb) with MIC values of 1.9 and 1.5 
g/mL, respectively. Manadomanzamines A and B also exhibit activitiesagainst human immunodeficiency virus (HIV-1) and AIDS opportunistic fungal infections.
g/mL, respectively. Manadomanzamines A and B also exhibit activitiesagainst human immunodeficiency virus (HIV-1) and AIDS opportunistic fungal infections.