Iodine-Promoted Construction of Polysubstituted 2,3-Dihydropyrroles from Chalcones and 尾-Enamine Ketones (Esters)
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- 作者：Yujin Li ; Hui Xu ; Mengming Xing ; Fang Huang ; Jianhong Jia ; Jianrong Gao
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：August 7, 2015
- 年：2015
- 卷：17
- 期：15
- 页码：3690-3693
- 全文大小：368K
- ISSN：1523-7052
文摘
A novel approach for the synthesis of a variety of polysubstituted trans-2,3-dihydropyrroles from a wide range of chalcones and 尾-enamine ketones (esters) via iodine-promoted tandem Michael/cyclization sequence has been developed, affording the desired products in moderate to excellent yields. This methodology is a highly efficient, convenient way to access functionalized 2,3-dihydropyrroles from readily accessible substrates under mild reaction conditions.