Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes
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- 作者：Xin Meng ; Wenlong Yao ; Jiansong Cheng ; Xu Zhang ; Lan Jin ; Hai Yu ; Xi Chen ; Fengshan Wang ; Hongzhi Cao
- 刊名：Journal of the American Chemical Society
- 出版年：2014
- 出版时间：April 9, 2014
- 年：2014
- 卷：136
- 期：14
- 页码：5205-5208
- 全文大小：327K
- 年卷期：v.136,no.14(April 9, 2014)
- ISSN：1520-5126
文摘
A novel chemoenzymatic approach for the synthesis of disialyl tetrasaccharide epitopes found as the terminal oligosaccharides of GD1伪, GT1a伪, and GQ1b伪 is described. It relies on chemical manipulation of enzymatically generated trisaccharides as conformationally constrained acceptors for regioselective enzymatic 伪2鈥?-sialylation. This strategy provides a new route for easy access to disialyl tetrasaccharide epitopes and their derivatives.