Palladium-Catalyzed Allylic C–H Oxidative Annulation for Assembly of Functionalized 2-Substituted Quinoline Derivatives
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- 作者：Chunsheng Li ; Jianxiao Li ; Yanni An ; Jianwen Peng ; Wanqing Wu ; Huanfeng Jiang
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：December 16, 2016
- 年：2016
- 卷：81
- 期：24
- 页码：12189-12196
- 全文大小：514K
- ISSN：1520-6904
文摘
An efficient and practical palladium-catalyzed aerobic oxidative approach to afford functionalized 2-substituted quinolines in moderate to good yields from readily available allylbenzenes with aniline is developed. The present annulation process has high functional-group tolerance and high atom economy, making it a valuable and practical method in synthetic and medicinal chemistry. Moreover, this transformation is supposed to proceed through oxidation of allylic C–H functionalization to form C–C and C–N bonds in one pot.