Synthesis of Oxazoles by Tandem Cycloisomerization/Allylic Alkylation of Propargyl Amides with Allylic Alcohols: Zn(OTf)2 as 蟺 Acid and 蟽 Acid Catalyst
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- 作者：Bin Wang ; Ying Chen ; Ling Zhou ; Jianwu Wang ; Chen-Ho Tung ; Zhenghu Xu
- 刊名：Journal of Organic Chemistry
- 出版年：2015
- 出版时间：December 18, 2015
- 年：2015
- 卷：80
- 期：24
- 页码：12718-12724
- 全文大小：447K
- ISSN：1520-6904
文摘
A Zn(OTf)2-catalyzed tandem cycloisomerization/allylic alkylation of N-(propargyl)arylamides and allylic alcohols to produce oxazole derivatives has been successfully developed. The zinc catalyst served as 蟺 acid and also 蟽 acid in this reaction. The target allylic oxazoles have been transformed into multisubstituted diene structures, which are potential aggregation-induced emission active optical materials.