A Convenient Synthesis of (S)-H4-BINOL and Its Derivatives via Hydrogenation of Monoesters of BINOL

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• 作者：Xinsheng Li*^† ; ; Qianchang Ding^† ; ; Jianfeng Ge^‡ ; ; Jianwu Xie^† ; ; Dongcheng Xu^† ;
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：February 20, 2009
• 年：2009
• 卷：74
• 期：4
• 页码：1785-1787
• 全文大小：131K
• 年卷期：v.74,no.4(February 20, 2009)
• ISSN：1520-6904

文摘

A new multigram synthesis of chiral (S)-H₄-BINOL and its derivatives in moderate to high yield (up to 83% total yield) via monoesterification of (S)-BINOL, hydrogenation, and saponification reaction was described. The two new monomethylated (S)-H₄-BINOL obtained may be useful materials in asymmetric catalysis.