Synthesis of Arylglycines from CO2 through 伪-Amino Organomanganese Species

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• 作者：Tsuyoshi Mita ; Jianyang Chen ; Yoshihiro Sato
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：April 18, 2014
• 年：2014
• 卷：16
• 期：8
• 页码：2200-2203
• 全文大小：293K
• 年卷期：v.16,no.8(April 18, 2014)
• ISSN：1523-7052

文摘

In the presence of three readily available chemicals, Mn powder, BF₃路OEt₂, and LiCl, N-acyl-N,O-acetals were successfully converted into the corresponding 伪-amino acids (arylglycine derivatives) under 1 atm of a CO₂ atmosphere in high yields. The LiCl additive is necessary in order to increase the solubility and the nucleophilicity of an organomanganese intermediate. The products thus obtained were transformed into free 伪-amino acids in two steps.