One-Pot Synthesis of 伪-Amino Acids from CO2 Using a Bismetal Reagent with Si鈥揃 Bond

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• 作者：Tsuyoshi Mita ; Jianyang Chen ; Masumi Sugawara ; Yoshihiro Sato
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：December 21, 2012
• 年：2012
• 卷：14
• 期：24
• 页码：6202-6205
• 全文大小：261K
• 年卷期：v.14,no.24(December 21, 2012)
• ISSN：1523-7052

文摘

In the presence of 1.1 equiv of PhMe₂Si-Bpin, 5 equiv of CsF, and 20 mol % of TsOH路H₂O, precursors of N-Boc-imines can be converted into the corresponding 伪-aryl or 伪-alkenyl glycine derivatives under gaseous CO₂ in moderate-to-high yields with a single operation. 伪-Isobutenyl glycine thus obtained can be further derivatized into various types of 伪-amino acids including N-Boc-leucine, serine, and glycine derivatives in short steps.