Targeted Paclitaxel by Conjugation to Iron Oxide and Gold Nanoparticles
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- 作者：Jih Ru Hwu ; Yu Sern Lin ; Thainashmuthu Josephrajan ; Ming-Hua Hsu ; Fong-Yu Cheng ; Chen-Sheng Yeh ; Wu-Chou Su ; Dar-Bin Shieh
- 刊名：Journal of the American Chemical Society
- 出版年：2009
- 出版时间：January 14, 2009
- 年：2009
- 卷：131
- 期：1
- 页码：66-68
- 全文大小：207K
- 年卷期：v.131,no.1(January 14, 2009)
- ISSN：1520-5126
文摘
The Fe3O4 nanoparticles, tailored with maleimidyl 3-succinimidopropionate ligands, were conjugated with paclitaxel molecules that were attached with a poly(ethylene glycol) (PEG) spacer through a phosphodiester moiety at the (C-2′)-OH position. The average number of paclitaxel molecules/nanoparticles was determined as 83. These nanoparticles liberated paclitaxel molecules upon exposure to phosphodiesterase.