Ru(II)-Catalyzed Selective C鈥揌 Amination of Xanthones and Chromones with Sulfonyl Azides: Synthesis and Anticancer Evaluation
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- 作者：Youngmi Shin ; Sangil Han ; Umasankar De ; Jihye Park ; Satyasheel Sharma ; Neeraj Kumar Mishra ; Eui-Kyung Lee ; Youngil Lee ; Hyung Sik Kim ; In Su Kim
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：October 3, 2014
- 年：2014
- 卷：79
- 期：19
- 页码：9262-9271
- 全文大小：580K
- ISSN：1520-6904
文摘
A ketone-assisted ruthenium-catalyzed selective amination of xanthones and chromones C鈥揌 bonds with sulfonyl azides is described. The reactions proceed efficiently with a broad range of substrates with excellent functional group compatibility. This protocol provides direct access to 1-aminoxanthones, 5-aminochromones, and 5-aminoflavonoid derivatives known to exhibit potent anticancer activity.