I2-Mediated Oxidative C鈥揘 Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from 伪,尾-Unsaturated Aldehydes/Ketones and Hydrazines
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- 作者：Xinting Zhang ; Jinfeng Kang ; Pengfei Niu ; Jie Wu ; Wenquan Yu ; Junbiao Chang
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：November 7, 2014
- 年：2014
- 卷：79
- 期：21
- 页码：10170-10178
- 全文大小：471K
- ISSN：1520-6904
文摘
An I2-mediated metal-free oxidative C鈥揘 bond formation methodology has been established for the regioselective pyrazole synthesis. This practical and eco-friendly one-pot protocol requires no isolation of the less stable intermediates hydrazones and provides a facile access to a variety of di-, tri-, and tetrasubstituted (aryl, alkyl, and/or vinyl) pyrazoles from readily available 伪,尾-unsaturated aldehydes/ketones and hydrazine salts.