Synthesis of 2-Benzylphenyl Ketones by Aryne Insertion into Unactivated C–C Bonds

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• 作者：Bin Rao ; Jinghua Tang ; Xiaoming Zeng
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：April 1, 2016
• 年：2016
• 卷：18
• 期：7
• 页码：1678-1681
• 全文大小：416K
• ISSN：1523-7052

文摘

A transition-metal-free procedure to access to functionalized 2-benzylphenyl ketones is described by direct insertion of arynes into benzylic C–C bonds. This reaction was promoted by cesium fluoride at room temperature, allowing the products to form in high selectivity and achieve good functional group tolerance.