文摘
Perfluorooctanesulfonylfluoride (POSF)-based compoundshave been manufactured and used in a variety of industrialapplications. These compounds degrade to perfluorooctanesulfonate (PFOS) which is regarded as a persistent end-stage metabolite and is found to accumulate in tissuesof humans and wildlife. PFOS, perfluorohexanesulfonate(PFHxS), perfluorooctanoate (PFOA), and perfluorooctanesulfonamide (PFOSA) have been found in human serafrom the United States. In this study, concentrations ofPFHxS, perfluorobutanesulfonate (PFBS), PFOS, perfluorohexanoic acid (PFHxA), PFOA, perfluorononanoic acid(PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoicacid (PFUnDA), perfluorododecanoic acid (PFDoDA), andPFOSA were measured in 85 samples of whole human bloodcollected from nine cities (eight provinces) in China,including Shenyang (Liaoning), Beijing (Hebei), Zhengzhou(Henan), Jintan (Jiangsu), Wuhan (Hubei), Zhoushan(Zhejiang), Guiyang (Guizhou), Xiamen (Fujian), and Fuzhou(Fujian). Among the 10 perfluorinated compounds (PFCs)measured, PFOS was the predominant compound. The meanconcentration of PFOS was greatest in samples collectedfrom Shenyang (79.2 ng/mL) and least in samples fromJintan (3.72 ng/mL). PFHxS was the next most abundantperfluorochemical in the samples. No age-related differencesin the concentrations of PFOA, PFOS, PFOSA, and PFHxSwere observed. Gender-related differences were found, withmales higher for PFOS and PFHxS, and females higher inPFUnDA. Concentrations of PFHxS were positively correlatedwith those of PFOS, while concentrations of PFNA,PFDA, and PFUnDA were positively correlated with thoseof PFOA. There were differences in the concentrationprofiles (percentage composition) of various PFCs in thesamples among the nine cities.