Hypoxia-Selective Antitumor Agents: Norsesterterpene Peroxides from the Marine Sponge Diacarnus levii Preferentially Suppress the Growth of Tumor Cells under Hypoxic Conditions

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• 作者：Jingqiu Dai ; Yang Liu ; Yu-Dong Zhou ; Dale G. Nagle
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：January 2007
• 年：2007
• 卷：70
• 期：1
• 页码：130 - 133
• 全文大小：54K
• 年卷期：v.70,no.1(January 2007)
• ISSN：1520-6025

文摘

As part of an ongoing research program to discover natural products that suppress the hypoxia-activated tumor survivalpathways, the lipid extract of the Papua New Guinea marine sponge Diacarnus levii was found to suppress hypoxia-induced HIF-1 activation and hypoxic tumor cell survival. Bioassay-guided isolation of D. levii yielded four newnorsesterterpene peroxides, diacarnoxides A-D. Diacarnoxide B exhibits a significantly enhanced ability to suppressthe growth of tumor cells under hypoxic conditions.