Maleimide and Maleic Anhydride Derivatives from the Mycelia of Antrodia cinnamomea and Their Nitric Oxide Inhibitory Activities in Macrophages

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• 作者：Ming-Der Wu ; Ming-Jen Cheng ; Bor-Cheh Wang ; Yi-Jen Yech ; Jinn-Tsyy Lai ; Yao-Haur Kuo ; Gwo-Fang Yuan ; Ih-Sheng Chen
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：July 2008
• 年：2008
• 卷：71
• 期：7
• 页码：1258-1261
• 全文大小：117K
• 年卷期：v.71,no.7(July 2008)
• ISSN：1520-6025

文摘

On cultivation of the fungus Antrodia cinnamomea (BCRC 36799) on a medium, the mycelium was extracted and evaluated for nitric oxide (NO) inhibitory activity. Bioactivity-directed fractionation led to the isolation of two new maleimide derivatives, antrocinnamomins A (1) and B (2), and two new maleic anhydride derivatives, antrocinnamomins C (3) and D (4), along with three known compounds, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione (5), 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrole-2,5-dione (6), and 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione (7). Structural elucidation of compounds 1−4 was carried out by spectroscopic data. Compound 1 displayed significant inhibitory effect on nitric oxide (NO) production.