Amphiphilic Polymer Micellar Disruption Based on Main-Chain Photodegradation

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• 作者：Min Tian ; Ruidong Cheng ; Jun Zhang ; Zhaotie Liu ; Zhongwen Liu ; Jinqiang Jiang
• 刊名：Langmuir
• 出版年：2016
• 出版时间：January 12, 2016
• 年：2016
• 卷：32
• 期：1
• 页码：12-18
• 全文大小：423K
• ISSN：1520-5827

文摘

The amphiphilic block copolymer poly(ethylene oxide)-b-poly(N,N′-dihydroxypyromellitimide-hexamethylene diisocyanate) (PEO-b-PNH) with photocleavable N–O urethanes has been prepared to investigate the photodegradation of the hydrophobic main chain and therefore the disruption of copolymer micelles. Measurements of absorption and emission spectra, optical transmittance, DLS analysis, and TEM observations were applied. It was shown that PEO-b-PNH could self-assemble into flower compound micelles in water. The photodegradation of the hydrophobic polyurethane within the micellar core upon irradiation with 365 nm light could be conveniently controlled by changing the irradiation intensity; furthermore, complete micellar disruption could be achieved when 42% of N–O urethanes were photocleaved. By using DOX as the hydrophobic guest, the drug release profile showed a linear leakage of DOX out of the swelling polymer micelles in the initial stage and thereafter a much more quick exponential decay of DOX precipitation because of the micellar disruption upon further irradiation. The diffusion experiment of the leaked DOX into buffer solution (pH 7.4) showed that the DOX leakage could be prominently accelerated by a very short time of 365 nm irradiation, indicating that the N–O photocleavage can serve as a “turn-on” switch for the release of DOX in aqueous media.