Verrucamides A鈥揇, Antibacterial Cyclopeptides from Myrothecium verrucaria

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• 作者：Xianwei Zou ; Shubin Niu ; Jinwei Ren ; Erwei Li ; Xingzhong Liu ; Yongsheng Che
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1111-1116
• 全文大小：760K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Four new cyclic tetradecapeptides, verrucamides A鈥揇 (1鈥?b>4), have been isolated from the solid-substrate fermentation culture of the ascomycete fungus Myrothecium verrucaria. The structures of these compounds, each featuring six N-methylated amino acid residues, were elucidated primarily by NMR and MS methods. The absolute configurations of 1鈥?b>4 were assigned by application of Marfey鈥檚 method on their acid hydrolysates. Compounds 1鈥?b>4 showed antimicrobial activity against the Gram-positive bacterium Staphylococcus aureus.