Catalytic Asymmetric Construction of Chiral Hydropyridazines via Conjugate Addition of N-Monosubstituted Hydrazones to Enones
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- 作者：Wenbin Wu ; Xiaoqian Yuan ; Juan Hu ; Xinxin Wu ; Yuan Wei ; Zunwu Liu ; Junzhu Lu ; Jinxing Ye
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：September 6, 2013
- 年：2013
- 卷：15
- 期：17
- 页码：4524-4527
- 全文大小：298K
- 年卷期：v.15,no.17(September 6, 2013)
- ISSN：1523-7052
文摘
The first example of a highly enantioselective and scalable formal diaza鈥揺ne reaction between N-monosubstituted hydrazones and enones catalyzed by a simple chiral primary-second diamine salt has been developed. The catalytic process provides a highly practical and stereoselective synthetic method for chiral hydropyridazines.