Self-Targeted, Shape-Assisted, and Controlled-Release Self-Delivery Nanodrug for Synergistic Targeting/Anticancer Effect of Cytoplasm and Nucleus of Cancer Cells
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- 作者：Yang Li ; Jinyan Lin ; Yu Huang ; Yanxiu Li ; Xiangrui Yang ; Hongjie Wu ; Shichao Wu ; Liya Xie ; Lizong Dai ; Zhenqing Hou
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2015
- 出版时间：November 25, 2015
- 年：2015
- 卷：7
- 期：46
- 页码：25553-25559
- 全文大小：458K
- ISSN：1944-8252
文摘
We constructed 10-hydroxycamptothecin (CPT) 鈥渘anodrugs鈥?with functionalization of lipid-PEG-methotrexate (MTX) to prepare high-drug-loaded, and sustained/controlled-release MTX-PEG-CPT nanorods (NRs), in which MTX drug itself can serve as a specific 鈥渢argeting ligand鈥? The self-targeted nanodrug can codeliver both CPT and MTX drugs with distinct anticancer mechanisms. Furthermore, MTX-PEG-CPT NRs significantly reduced burst release, improved blood circulation and tumor accumulation, enhanced cellular uptake, and synergistically increased anticancer effect against tumor cells compared with MTX-PEG-CPT nanospheres (NSs) and either both free drugs or individual free drug. Therefore, the synergistic targeting/therapeuticy nano-multi-drug codelivery assisted by shape design may advantageously offer a promising new strategy for nanomedicine.