Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug鈥揚hospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release

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• 作者：Yang Li ; Jinyan Lin ; Xiangrui Yang ; Yanxiu Li ; Shichao Wu ; Yu Huang ; Shefang Ye ; Liya Xie ; Lizong Dai ; Zhenqing Hou
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：August 19, 2015
• 年：2015
• 卷：7
• 期：32
• 页码：17573-17581
• 全文大小：502K
• ISSN：1944-8252

文摘

Integrating advantages of mitomycin C (MMC)鈥損hospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC鈥損hospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug鈥損hospholipid complex-based targeted drug delivery system for sustained/controlled drug release.