Supramolecular Micelles Constructed by Crown Ether-Based Molecular Recognition

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• 作者：Xiaofan Ji ; Jinying Li ; Jianzhuang Chen ; Xiaodong Chi ; Kelong Zhu ; Xuzhou Yan ; Mingming Zhang ; Feihe Huang
• 刊名：Macromolecules
• 出版年：2012
• 出版时间：August 28, 2012
• 年：2012
• 卷：45
• 期：16
• 页码：6457-6463
• 全文大小：455K
• 年卷期：v.45,no.16(August 28, 2012)
• ISSN：1520-5835

文摘

A novel supramolecular amphiphilic polymer constructed by crown ether-based molecular recognition has been fabricated and demonstrated to self-assemble into core鈥搒hell supramolecular micelles in water. The reversible transition between assembled and disassembled structures can be achieved by changing the pH. This transition was used to realize the controlled release of small molecules. The supramolecular micelle was characterized by various techniques including conductivity, transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and fluorescence titration. TEM images showed dark gray spherical aggregates, and the mean size of the micelles was 50 nm in diameter and of uniformly dispersed size, in good agreement with the DLS results. The release of hydrophobic molecules from the micelles was realized by adding acid (aqueous HCl), weakening the host鈥揼uest interactions and leading to disassembly of the supramolecular micelles.