Phthalate Esters in Human Milk: Concentration Variations over a 6-Month Postpartum Time
详细信息 查看全文
- 作者：Jiping Zhu ; Susan P. Phillips ; Yong-Lai Feng ; Xiaofeng Yang
- 刊名：Environmental Science & Technology
- 出版年：2006
- 出版时间：September 1, 2006
- 年：2006
- 卷：40
- 期：17
- 页码：5276 - 5281
- 全文大小：150K
- 年卷期：v.40,no.17(September 1, 2006)
- ISSN：1520-5851
文摘
The present study investigated the levels of phthalateesters in a total of 86 human milk samples collected among21 breast-feeding mothers over a 6-month postpartumtime. Di(2-ethylhexyl) phthalate (DEHP) was the predominantester with the arithmetic mean value of 222 ng g-1(range: 156-398 ng g-1, 95% confidence limit), followedby dibutyl phthalate (DBP), 0.87 (range: 0.62-1.2) ng g-1.Diethyl phthalate (DEP), with a mean of 0.31 ng g-1, wasdetected in only a small number of samples. Weak correlationsbetween lipid content and levels of phthalate esterswere observed. The levels of phthalate esters in humanmilk fluctuated over the 6-month period; this may indicatea need for multiple sample collection, to calculateaverage concentrations over the feeding period. Multiplesample collection would provide a better estimate of theexposure of breast-fed infants to phthalate in humanmilk. For infants relying on breast-feeding, the mean dailyintake over the first 6-month period considering a 7 kginfant consuming 750 g of milk was estimated at 167 
gd-1 for DEHP and less than 1 g d-1 for DBP and DEP. Whilethe nutritional and social benefits of breast-feeding arewell established, the potential transfer of phthalate estersfrom mothers to breast-fed infants should also berecognized.
gd-1 for DEHP and less than 1 g d-1 for DBP and DEP. Whilethe nutritional and social benefits of breast-feeding arewell established, the potential transfer of phthalate estersfrom mothers to breast-fed infants should also berecognized.