Facile Synthesis of Ultrasmall and Hexagonal NaGdF4: Yb3+, Er3+ Nanoparticles with Magnetic and Upconversion Imaging Properties

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• 作者：Jiyoung Ryu ; Hye-Young Park ; Keumhyun Kim ; Heeyeon Kim ; Jung Ho Yoo ; Moonsik Kang ; Kangbin Im ; Regis Grailhe ; Rita Song
• 刊名：Journal of Physical Chemistry C
• 出版年：2010
• 出版时间：December 16, 2010
• 年：2010
• 卷：114
• 期：49
• 页码：21077-21082
• 全文大小：345K
• 年卷期：v.114,no.49(December 16, 2010)
• ISSN：1932-7455

文摘

Synthesis of nanomaterials with multi-imaging modality is of great importance in clinical molecular imaging and diagnostics. This work reports novel synthetic strategy to create ultrasmall and hexagonal upconversion nanoparticles (UCNPs), β-NaGdF₄: Yb³⁺, Er³⁺, and β-NaGdF₄: Yb³⁺, Tm³⁺, with inherent magnetic and efficient upconversion properties. The use of new combination of lanthanide chloride and sodium TFA as the precursors for UCNPs gave the best results in terms of size (10−40 nm), crystallinity and morphology, and proved to be cost- and time-saving. Water solubilization of both NaGdF₄: Yb³⁺, Er³⁺, and β-NaGdF₄: Yb³⁺, Tm³⁺ UCNPs was achieved by homogeneous polymer coating using amphiphilic poly(acrylic acid) derivatives. The strong upconversion and magnetic properties were maintained after extensive polymer coating process. To see the potential of the UCNPs for biological applications, the surface of NaGdF₄: Yb³⁺, Er³⁺ UCNPs were functionalized with Ni-nitrilotriacetate (NiNTA) moiety. The remarkable specificity of these NiNTA-UCNPs for the oligohistidine peptide was clearly shown by both magnetic resonance and optical imaging. Finally, the cellular uptake of these UCNPs was investigated by fluorescence microscope using spectral imaging technique.