Isolactarane and Sterpurane Sesquiterpenoids from the Basidiomycete Phlebia uda

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• 作者：Anja Sch眉ffler ; Beate Wollinsky ; Timm Anke ; Johannes C. Liermann ; Till Opatz
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：July 27, 2012
• 年：2012
• 卷：75
• 期：7
• 页码：1405-1408
• 全文大小：230K
• 年卷期：v.75,no.7(July 27, 2012)
• ISSN：1520-6025

文摘

Three new sesquiterpenoids, named udasterpurenol A, udalactarane A, and udalactarane B, as well as the known compounds hyphodontal and sterpuric acid have been isolated from the basidiomycete Phlebia uda. These compounds represent the first natural products described from this species. The structures were elucidated by NMR spectroscopy and mass spectrometry. Udalactaranes A and B were isolated as mixtures with their respective epimeric acetals. These mixtures inhibited the spore germination of the plant pathogenic fungus Fusarium graminearum at 10 and 5 渭g/mL, respectively, and were active against Jurkat cells with IC₅₀ values of 101 and 42 渭M, respectively.