Bisoxazoline-Lewis Acid-Catalyzed Direct-Electron Demand oxo-Hetero-Diels-Alder Reactions of N-Oxy-pyridine Aldehyde and Ketone Derivatives

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• 作者：Aitor Landa ; Bo Richter ; Rasmus Lyng Johansen ; Anna Minkkilä ; Karl Anker J//pubs.acs.org/images/gifchars/oslash.gif" border="0">rgensen
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：January 5, 2007
• 年：2007
• 卷：72
• 期：1
• 页码：240 - 245
• 全文大小：129K
• 年卷期：v.72,no.1(January 5, 2007)
• ISSN：1520-6904

文摘

A general catalytic oxo-hetero-Diels-Alder reaction for pro-chiral aldehyde and ketone N-oxy-pyridinesis presented. The catalytic and asymmetric oxo-hetero-Diels-Alder reaction of electron-rich dienes withN-oxy-pyridine-2-carbaldehyde and ketone derivatives, catalyzed by chiral copper(II)-bisoxazolinecomplexes, gives optically active six-membered oxygen heterocycles in moderate to good yields andwith excellent enantioselectivities.