Cytotoxic Guanidine Alkaloids from a French Polynesian Monanchora n. sp. Sponge

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• 作者：Amr El-Demerdash ; Céline Moriou ; Marie-Thérèse Martin ; Alice de Souza Rodrigues-Stien ; Sylvain Petek ; Marina Demoy-Schneider ; Kathryn Hall ; John N. A. Hooper ; Cécile Debitus ; Ali Al-Mourabit
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：August 26, 2016
• 年：2016
• 卷：79
• 期：8
• 页码：1929-1937
• 全文大小：447K
• 年卷期：0
• ISSN：1520-6025

文摘

Four bicyclic and three pentacyclic guanidine alkaloids (1–7) were isolated from a French Polynesian Monanchora n. sp. sponge, along with the known alkaloids monalidine A (8), enantiomers 9–11 of known natural product crambescins, and the known crambescidins 12–15. Structures were assigned by spectroscopic data interpretation. The relative and absolute configurations of the alkaloids were established by analysis of ¹H NMR and NOESY spectra and by circular dichroism analysis. The new norcrambescidic acid (7) corresponds to interesting biosynthetic variation within the pentacyclic core. All compounds exhibited antiproliferative and cytotoxic efficacy against KB, HCT116, HL60, MRC5, and B16F10 cancer cells, with IC₅₀ values ranging from 4 nM to 10 μM.