Analog Computation by DNA Strand Displacement Circuits

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• 作者：Tianqi Song ; Sudhanshu Garg ; Reem Mokhtar ; Hieu Bui ; John Reif
• 刊名：ACS Synthetic Biology
• 出版年：2016
• 出版时间：August 19, 2016
• 年：2016
• 卷：5
• 期：8
• 页码：898-912
• 全文大小：885K
• 年卷期：0
• ISSN：2161-5063

文摘

DNA circuits have been widely used to develop biological computing devices because of their high programmability and versatility. Here, we propose an architecture for the systematic construction of DNA circuits for analog computation based on DNA strand displacement. The elementary gates in our architecture include addition, subtraction, and multiplication gates. The input and output of these gates are analog, which means that they are directly represented by the concentrations of the input and output DNA strands, respectively, without requiring a threshold for converting to Boolean signals. We provide detailed domain designs and kinetic simulations of the gates to demonstrate their expected performance. On the basis of these gates, we describe how DNA circuits to compute polynomial functions of inputs can be built. Using Taylor Series and Newton Iteration methods, functions beyond the scope of polynomials can also be computed by DNA circuits built upon our architecture.