Electrosynthesis of Substituted 1H-Indoles from o-Nitrostyrenes

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• 作者：Peng Du ; Jonathan L. Brosmer ; Dennis G. Peters
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：August 5, 2011
• 年：2011
• 卷：13
• 期：15
• 页码：4072-4075
• 全文大小：663K
• 年卷期：v.13,no.15(August 5, 2011)
• ISSN：1523-7052

文摘

A novel procedure has been devised for the synthesis of derivatives of 1H-indole that is based on the direct, room-temperature electrochemical reduction of substituted o-nitrostyrenes at carbon cathodes in N,N-dimethylformamide containing tetramethylammonium tetrafluoroborate as supporting electrolyte and in the presence of a 10-fold molar excess of a proton donor (phenol or methyl 3-oxobutanoate).