Investigations of Enantiopure Nicotine Haptens Using an Adjuvanting Carrier in Anti-Nicotine Vaccine Development
详细信息 查看全文
- 作者：Nicholas T. Jacob ; Jonathan W. Lockner ; Joel E. Schlosburg ; Beverly A. Ellis ; Lisa M. Eubanks ; Kim D. Janda
- 刊名：Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：March 24, 2016
- 年：2016
- 卷：59
- 期：6
- 页码：2523-2529
- 全文大小：402K
- ISSN：1520-4804
文摘
Despite efforts to produce suitable smoking cessation aids, addiction to nicotine continues to carry a substantive risk of recidivism. An attractive alternative to current therapies is the pharmacokinetic strategy of antinicotine vaccination. A major hurdle in the development of the strategy has been to elicit a sufficiently high antibody concentration to curb nicotine distribution to the brain. Herein, we detail investigations into a new hapten design, which was able to elicit an antibody response of significantly higher specificity for nicotine. We also explore the use of a mutant flagellin carrier protein with adjuvanting properties. These studies underlie the feasibility of improvement in antinicotine vaccine formulations to move toward clinical efficacy.