Porphyrin-Cross-Linked Hydrogel for Fluorescence-Guided Monitoring and Surgical Resection

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• 作者：Jonathan F. Lovell ; Aron Roxin ; Kenneth K. Ng ; Qiaochu Qi ; Jesse D. McMullen ; Ralph S. DaCosta ; Gang Zheng
• 刊名：Biomacromolecules
• 出版年：2011
• 出版时间：September 12, 2011
• 年：2011
• 卷：12
• 期：9
• 页码：3115-3118
• 全文大小：814K
• 年卷期：v.12,no.9(September 12, 2011)
• ISSN：1526-4602

文摘

We demonstrate that porphyrins can be used as efficient cross-linkers to generate a new class of hydrogels with enabling optical properties. Tetracarboxylic acid porphyrins reacted with PEG diamines to form a condensation polyamide in a range of appropriate conditions, with respect to reaction time, diisopropylethylamine initiator concentration, porphyrin-to-PEG ratio, porphyrin concentration, and PEG size. The network structure of the hydrogel maintained a porphyrin spacing that prevented excessive fluorescence self-quenching despite high porphyrin density. The near-infrared properties readily enabled low background, noninvasive fluorescence monitoring of the implanted hydrogel in vivo, as well as its image-guided surgical removal in real time using a low-cost fluorescence camera prototype. Emission could be tuned by incorporating copper metalloporphyrins into the network. The approach of creating hydrogels using cross-linking porphyrin comonomers creates opportunities for new polymer designs with strong optical character.