Biocompatible Hydrogels by Oxime Click Chemistry

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• 作者：Gregory N. Grover ; Jonathan Lam ; Thi H. Nguyen ; Tatiana Segura ; Heather D. Maynard
• 刊名：Biomacromolecules
• 出版年：2012
• 出版时间：October 8, 2012
• 年：2012
• 卷：13
• 期：10
• 页码：3013-3017
• 全文大小：331K
• 年卷期：v.13,no.10(October 8, 2012)
• ISSN：1526-4602

文摘

Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.