Goldilocks Catalysts: Computational Insights into the Role of the 3,3′ Substituents on the Selectivity of BINOL-Derived Phosphoric Acid Catalysts

详细信息    查看全文

• 作者：Jolene P. Reid ; Jonathan M. Goodman
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：June 29, 2016
• 年：2016
• 卷：138
• 期：25
• 页码：7910-7917
• 全文大小：586K
• 年卷期：0
• ISSN：1520-5126

文摘

BINOL-derived phosphoric acids provide effective asymmetric catalysis for many organic reactions. Catalysts based on this scaffold show a large structural diversity, especially in the 3,3′ substituents, and little is known about the molecular requirements for high selectivity. As a result, selection of the best catalyst for a particular transformation requires a trial and error screening process, as the size of the 3,3′ substituents is not simply related to their efficacy: the right choice is neither too large nor too small. We have developed an approach to identify and quantify structural features on the catalyst that determine selectivity. We show that the application of quantitative steric parameters (a new measure, AREA(θ), and rotation barrier) to an imine hydrogenation reaction allows the identification of catalyst features necessary for efficient stereoinduction, validated by QM/MM hybrid calculations.