In Vivo Glucose Measurement by Surface-Enhanced Raman Spectroscopy

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• 作者：Douglas A. Stuart ; Jonathan M. Yuen ; Nilam Shah ; Olga Lyandres ; Chanda R. Yonzon ; Matthew R. Glucksberg ; Joseph T. Walsh ; Richard P. Van Duyne
• 刊名：Analytical Chemistry
• 出版年：2006
• 出版时间：October 15, 2006
• 年：2006
• 卷：78
• 期：20
• 页码：7211 - 7215
• 全文大小：283K
• 年卷期：v.78,no.20(October 15, 2006)
• ISSN：1520-6882

文摘

This paper presents the first in vivo application of surface-enhanced Raman scattering (SERS). SERS was used toobtain quantitative in vivo glucose measurements from ananimal model. Silver film over nanosphere surfaces werefunctionalized with a two-component self-assembled monolayer, and subcutaneously implanted in a Sprague-Dawley rat such that the glucose concentration of theinterstitial fluid could be measured by spectroscopicallyaddressing the sensor through an optical window. Thesensor had relatively low error (RMSEC = 7.46 mg/dL(0.41 mM) and RMSEP = 53.42 mg/dL (2.97 mM).