Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis

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• 作者：Jaeyoung Kwon ; Hyaemin Lee ; Yeo Dae Yoon ; Bang Yeon Hwang ; Yuanqiang Guo ; Jong Soon Kang ; Jae-Jin Kim ; Dongho Lee
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：June 24, 2016
• 年：2016
• 卷：79
• 期：6
• 页码：1689-1693
• 全文大小：355K
• 年卷期：0
• ISSN：1520-6025

文摘

Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.